Antonia Sedaño
- Born: 1679, Querétaro, Nueva España 252
- Marriage: Juan Lorenzo de Medina
- Died: Bef 1726, Nuevo Méjico, Nueva España
 Noted events in her life were:
• Original Settler, 1695, Santa Cruz de la Cañada, Nuevo Méjico, Nueva España. 1510
• Background Information. 252
When Antonia Sedano came to New Mexico with her husband Juan Lorenzo de Medina, she was fourteen, the daughter of Pedro Sedano, and a native of Querétaro. She was described as fair and pockmarked, with a scar on the left eyebrown. Her sister was Josefa Sedano, who married Nicolás Jirón.
~ Origins of New Mexico Families: A Genealogy of the Spanish Colonial Period, p. 226
Antonia married Juan Lorenzo de Medina, son of José de Medina and Unknown. (Juan Lorenzo de Medina was born in 1673 in Ciudád de Méjico, Nueva España 252 and died on 4 Jul 1731 in Santa Fé, Nuevo Méjico, Nueva España 252.)
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