Francisco Macedonio Padilla
- Born: Abt 1770, Los Chaves, Nuevo Méjico, Nueva España
- Marriage: María Ysabel Chávez on 29 Jun 1800 in Tomé, Nuevo Méjico, Nueva España 46
Francisco married María Ysabel Chávez, daughter of Francisco Duran y Chávez and María Gertrudis Álvarez del Castillo, on 29 Jun 1800 in Tomé, Nuevo Méjico, Nueva España.46 (María Ysabel Chávez was born about 1777 in Los Chaves, Nuevo Méjico, Nueva España.)
 Noted events in their marriage were:
• Marriage Record: 46
29 Jun 1800, Francisco Macedonio Padilla (español, 30), son of Pedro Padilla and Victoria Chaves (deceased) of Fifth Plaza de los Chaves, married María Ysabel Chaves (española, 23), daughter of Francisco Chaves and María Gertrudis Albarez del Castillo (deceased) of the Sixth Plaza de los Chaves. Padrinos: José Sanches and his wife María Guadalupe Padilla.
Matrimonios de Immaculate Concepción de Tomé y Nuestra Señora de Belén, p. 24
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